The study, led by Professor Valerie Speirs, will focus on cancer-associated fibroblasts (CAFs), support cells that influence tumour growth and response to treatment. Despite around 400 men in the UK being diagnosed with breast cancer annually, with approximately 40 in Scotland, research and clinical trials predominantly focus on women, leading to delayed diagnoses and limited treatment evidence for men.
The research will explore how CAFs respond to hormones like oestrogen and androgens, and whether their activity differs between male and female tumours, potentially fuelling tumour growth in men. Professor Speirs stated, “Male breast cancer has been understudied for decades. By mapping the cells and signals that shape the disease in men, we hope to open the door to more personalised treatments and ensure men are no longer left behind in breast cancer research.”
“"Our study launches during Breast Cancer Awareness Month, at a moment when male breast cancer is receiving rare national visibility. ITV's flagship soap, Coronation Street’s storyline has prompted thousands of viewers to seek information about symptoms and risk factors, with charities reporting spikes in website traffic and helpline calls. This research aims to build on that momentum by addressing the scientific gaps that contribute to late diagnosis and limited treatment options for men."
Simon Vincent, chief scientific officer at Breast Cancer Now, highlighted the vital nature of such research, stating, “While male breast cancer is rare, around 400 men are diagnosed each year in the UK. Research like this is vital to improving our understanding of the disease and could pave the way for more tailored treatments and better outcomes for men diagnosed with it.” Samples from the Breast Cancer Now Biobank are supporting the study.
The project involves international collaborations, including GEICAM, Spain’s leading breast cancer research group, and the Male Breast Cancer Global Alliance. The source text also includes the personal story of Dave Talbot, who was diagnosed in 2015 and has since become a passionate advocate for male breast cancer research, highlighting the importance of early diagnosis and tailored treatments.
